Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1051)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0454979	0.0998207	0.6532146
Weighted median	23	-0.0090710	0.0575164	0.8746845
Inverse variance weighted	23	-0.0123719	0.0390157	0.7511669
Simple mode	23	0.0053961	0.0968746	0.9560818
Weighted mode	23	-0.0395250	0.0650568	0.5497093

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.16305	21	0.5109555
Inverse variance weighted	20.29304	22	0.5647154

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020343	0.0056423	0.7220482

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000618	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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