Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1050)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1260373	0.1021388	0.2308424
Weighted median	23	0.0341650	0.0607437	0.5738129
Inverse variance weighted	23	0.0340799	0.0398825	0.3928244
Simple mode	23	-0.0723755	0.1190011	0.5492884
Weighted mode	23	0.0012623	0.0872701	0.9885901

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.98715	21	0.4002509
Inverse variance weighted	22.98885	22	0.4023593

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0056471	0.0057734	0.3391458

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007197	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8