Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 105)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1229985	0.0998207	0.2314953
Weighted median	23	0.0084818	0.0521572	0.8708183
Inverse variance weighted	23	-0.0115408	0.0390156	0.7673832
Simple mode	23	-0.0039958	0.0799129	0.9605725
Weighted mode	23	-0.0011436	0.0592437	0.9847737

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.27169	21	0.8988098
Inverse variance weighted	15.41584	22	0.8437829

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.008262	0.0056423	0.1579246

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004698	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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