Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1049)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0663357	0.1006031	0.5168178
Weighted median	23	0.0127601	0.0593663	0.8298147
Inverse variance weighted	23	0.0035637	0.0390153	0.9272220
Simple mode	23	-0.0498472	0.1020814	0.6301633
Weighted mode	23	0.0250551	0.0850479	0.7710619

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.33102	21	0.4388947
Inverse variance weighted	21.79779	22	0.4720126

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0038548	0.0056866	0.5052473

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006608	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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