Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1048)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0063849	0.0998212	0.9496047
Weighted median	23	0.0234096	0.0535563	0.6620371
Inverse variance weighted	23	-0.0105935	0.0390159	0.7859935
Simple mode	23	-0.0029616	0.0865950	0.9730260
Weighted mode	23	0.0142471	0.0622514	0.8210883

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.31392	21	0.6290609
Inverse variance weighted	18.31602	22	0.6870956

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002585	0.0056424	0.9638983

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005573	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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