Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1047)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1198204	0.0998195	0.2433617
Weighted median	23	-0.0297811	0.0551986	0.5895241
Inverse variance weighted	23	-0.0438191	0.0390154	0.2613852
Simple mode	23	-0.0313872	0.1053952	0.7686462
Weighted mode	23	-0.0261250	0.0736380	0.7261363

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.64069	21	0.7326436
Inverse variance weighted	19.81277	22	0.5947502

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0100491	0.0056423	0.0893781

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006386	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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