Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1046)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0910757	0.0998208	0.3719186
Weighted median	23	0.0581328	0.0555321	0.2951770
Inverse variance weighted	23	0.0450799	0.0390158	0.2479160
Simple mode	23	0.1196803	0.0945163	0.2186712
Weighted mode	23	0.0608504	0.0677510	0.3788318

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.47326	21	0.6820496
Inverse variance weighted	17.72387	22	0.7222287

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0028246	0.0056423	0.6218544

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005775	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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