Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1045)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0530678	0.0998215	0.6005634
Weighted median	23	0.0142437	0.0522557	0.7851780
Inverse variance weighted	23	0.0164173	0.0390160	0.6739135
Simple mode	23	0.0382307	0.0852792	0.6583205
Weighted mode	23	0.0298725	0.0611075	0.6297850

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.60720	21	0.8421335
Inverse variance weighted	14.76631	22	0.8720700

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0022507	0.0056424	0.6939998

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004528	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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