Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1044)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0670188	0.1039956	0.5262682
Weighted median	23	-0.0070440	0.0540120	0.8962376
Inverse variance weighted	23	0.0421125	0.0409235	0.3034545
Simple mode	23	-0.0281941	0.0875689	0.7505188
Weighted mode	23	-0.0250977	0.0621287	0.6901391

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.79335	21	0.3550946
Inverse variance weighted	24.20412	22	0.3366212

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0067017	0.0058783	0.2670915

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007687	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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