Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1043)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0565982	0.0998213	0.5767284
Weighted median	23	-0.0257698	0.0521271	0.6210487
Inverse variance weighted	23	-0.0480063	0.0390158	0.2185358
Simple mode	23	-0.0175943	0.0902522	0.8472241
Weighted mode	23	-0.0111107	0.0611734	0.8575386

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.04126	21	0.820876
Inverse variance weighted	16.33740	22	0.798795

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0064237	0.0056424	0.2677411

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005409	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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