Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1042)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0702570	0.0998212	0.4892712
Weighted median	23	-0.0332165	0.0570497	0.5604062
Inverse variance weighted	23	-0.0036413	0.0390158	0.9256423
Simple mode	23	-0.0588106	0.0969332	0.5502521
Weighted mode	23	-0.0104120	0.0726211	0.8872999

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.24898	21	0.8586688
Inverse variance weighted	14.89586	22	0.8666684

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0045381	0.0056424	0.430243

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004517	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8