Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1041)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1039296	0.0998207	0.3096392
Weighted median	23	-0.0103080	0.0549525	0.8512053
Inverse variance weighted	23	-0.0205472	0.0390157	0.5984446
Simple mode	23	-0.0139496	0.0869028	0.8739369
Weighted mode	23	-0.0169814	0.0606831	0.7822170

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.47971	21	0.7421217
Inverse variance weighted	17.30329	22	0.7464052

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0051205	0.0056423	0.374432

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005327	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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