Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1040)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0346641	0.1137947	0.7636545
Weighted median	23	0.0112923	0.0580442	0.8457485
Inverse variance weighted	23	0.0157820	0.0436946	0.7179581
Simple mode	23	0.0836779	0.1049746	0.4338980
Weighted mode	23	-0.0061090	0.0713462	0.9325389

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.29205	21	0.1613941
Inverse variance weighted	27.59351	22	0.1895465

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030979	0.0064322	0.6350562

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008411	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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