Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 104)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0923722	0.0998196	0.3652756
Weighted median	23	-0.0154724	0.0590391	0.7932673
Inverse variance weighted	23	-0.0793074	0.0390154	0.0420806
Simple mode	23	-0.2088977	0.1164044	0.0864739
Weighted mode	23	0.0117658	0.0771940	0.8802460

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.56888	21	0.6760992
Inverse variance weighted	17.58910	22	0.7300536

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008023	0.0056423	0.8882808

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006582	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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