Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1039)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0236831	0.1326202	0.8599806
Weighted median	23	-0.0976169	0.0554488	0.0783254
Inverse variance weighted	23	-0.0737801	0.0514072	0.1512274
Simple mode	23	-0.1882311	0.0896718	0.0475036
Weighted mode	23	-0.1122839	0.0615106	0.0815416

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.06941	21	0.0165279
Inverse variance weighted	38.19468	22	0.0174213

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0059852	0.0074963	0.4335647

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012657	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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