Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1038)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0215690	0.0998208	0.8310128
Weighted median	23	-0.0082679	0.0564158	0.8834846
Inverse variance weighted	23	0.0551073	0.0390159	0.1578229
Simple mode	23	0.2437190	0.1035662	0.0279594
Weighted mode	23	-0.0279697	0.0628558	0.6606808

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.79281	21	0.7811768
Inverse variance weighted	15.92606	22	0.8195386

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020596	0.0056423	0.7187449

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005431	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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