Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1037)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0373110	0.0998193	0.7123109
Weighted median	23	-0.0072181	0.0579727	0.9009129
Inverse variance weighted	23	0.0029674	0.0390154	0.9393743
Simple mode	23	-0.0355700	0.0965581	0.7161113
Weighted mode	23	0.0051383	0.0689592	0.9412761

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.56296	21	0.4858958
Inverse variance weighted	20.70268	22	0.5391721

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002109	0.0056423	0.7123051

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006275	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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