Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1035)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1318091	0.0998205	0.2008927
Weighted median	23	0.0092032	0.0555907	0.8685083
Inverse variance weighted	23	0.0128273	0.0390158	0.7423280
Simple mode	23	-0.0358564	0.0965554	0.7139252
Weighted mode	23	-0.0078868	0.0624117	0.9005892

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.58391	21	0.6118123
Inverse variance weighted	21.06199	22	0.5169099

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0088821	0.0056423	0.1303895

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006415	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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