Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1034)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1020162	0.1239837	0.4198564
Weighted median	23	0.0814630	0.0591056	0.1681221
Inverse variance weighted	23	0.0716361	0.0474257	0.1309181
Simple mode	23	0.1038768	0.1100276	0.3553735
Weighted mode	23	0.1001970	0.0668849	0.1483318

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.39861	21	0.0533257
Inverse variance weighted	32.50794	22	0.0691391

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018656	0.0070082	0.7926742

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010872	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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