Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1033)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0448941	0.0998214	0.6575025
Weighted median	23	-0.0366714	0.0555660	0.5092793
Inverse variance weighted	23	-0.0445913	0.0390159	0.2530798
Simple mode	23	-0.0829200	0.0823940	0.3251723
Weighted mode	23	-0.0422496	0.0647356	0.5207452

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.99512	21	0.8698086
Inverse variance weighted	13.99513	22	0.9016518

Test for directional horizontal pleiotropy

egger_intercept	se	pval
1.86e-05	0.0056424	0.9974016

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004637	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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