Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1032)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0155347	0.1121005	0.8911034
Weighted median	23	0.0564208	0.0582762	0.3329634
Inverse variance weighted	23	0.0102836	0.0428105	0.8101664
Simple mode	23	0.0957584	0.0914374	0.3063512
Weighted mode	23	0.0377374	0.0603183	0.5379895

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.48477	21	0.1885647
Inverse variance weighted	26.48803	22	0.2313190

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003225	0.0063365	0.9598927

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008048	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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