Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1031)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0107745	0.0998203	0.9150686
Weighted median	23	0.0278569	0.0563691	0.6211742
Inverse variance weighted	23	-0.0085572	0.0390156	0.8263955
Simple mode	23	0.0345953	0.0981162	0.7277477
Weighted mode	23	0.0450131	0.0778875	0.5691836

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.03702	21	0.7675673
Inverse variance weighted	16.08129	22	0.8118308

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0011872	0.0056423	0.8353819

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004888	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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