Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1030)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0227119	0.0998201	0.8222135
Weighted median	23	-0.0111660	0.0584701	0.8485502
Inverse variance weighted	23	-0.0095742	0.0390154	0.8061497
Simple mode	23	0.0131786	0.0950863	0.8910301
Weighted mode	23	-0.0052956	0.0731545	0.9429466

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.68806	21	0.7298334
Inverse variance weighted	16.70850	22	0.7792380

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008068	0.0056423	0.8876628

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005081	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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