Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 103)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0556500	0.1028828	0.5942635
Weighted median	23	0.0071162	0.0555746	0.8981114
Inverse variance weighted	23	0.0353481	0.0393310	0.3687939
Simple mode	23	0.0191665	0.0996411	0.8492284
Weighted mode	23	0.0536457	0.0740757	0.4765736

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.30839	21	0.3819291
Inverse variance weighted	22.35722	22	0.4387481

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012467	0.0058154	0.8323155

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007023	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8