Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1029)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1958462	0.0998200	0.0631523
Weighted median	23	-0.0144400	0.0575401	0.8018481
Inverse variance weighted	23	-0.0651785	0.0428847	0.1285473
Simple mode	23	0.0162235	0.0907860	0.8598083
Weighted mode	23	0.0030020	0.0582637	0.9593721

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.50886	21	0.6166141
Inverse variance weighted	26.57986	22	0.2276196

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0160293	0.0056422	0.0097864

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00089	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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