Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1028)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0282744	0.0998199	0.7797553
Weighted median	23	0.0334884	0.0571563	0.5579367
Inverse variance weighted	23	-0.0019488	0.0390155	0.9601622
Simple mode	23	0.0557396	0.0943448	0.5606704
Weighted mode	23	0.0530542	0.0734127	0.4774874

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.05702	21	0.5814820
Inverse variance weighted	19.13912	22	0.6367227

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0016167	0.0056423	0.7772847

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00058	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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