Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1027)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1760425	0.1168777	0.1469083
Weighted median	23	-0.0022515	0.0542397	0.9668891
Inverse variance weighted	23	0.0149941	0.0478664	0.7540906
Simple mode	23	-0.0540561	0.0800328	0.5064441
Weighted mode	23	-0.0302757	0.0615190	0.6274987

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.79048	21	0.1191232
Inverse variance weighted	33.11362	22	0.0602934

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0117314	0.0066064	0.0902667

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010078	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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