Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1026)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0326948	0.0998207	0.7465058
Weighted median	23	-0.0556665	0.0553860	0.3148655
Inverse variance weighted	23	-0.0525130	0.0390156	0.1783185
Simple mode	23	-0.0550739	0.0916004	0.5538248
Weighted mode	23	-0.0404843	0.0662921	0.5476589

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.26505	21	0.7545788
Inverse variance weighted	16.31158	22	0.8001269

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001217	0.0056423	0.8313057

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005492	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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