Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1025)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0465316	0.0998194	0.6459017
Weighted median	23	0.0552448	0.0604377	0.3606759
Inverse variance weighted	23	-0.0184374	0.0390152	0.6365210
Simple mode	23	0.0955180	0.1338243	0.4828818
Weighted mode	23	0.1113425	0.0868406	0.2131377

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.64154	21	0.4810134
Inverse variance weighted	21.14155	22	0.5120051

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039898	0.0056423	0.4872682

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006474	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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