Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1024)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0609858	0.1281656	0.6391038
Weighted median	23	-0.0070694	0.0602590	0.9066086
Inverse variance weighted	23	-0.0246261	0.0495526	0.6192109
Simple mode	23	-0.0039607	0.1160558	0.9730831
Weighted mode	23	0.0088775	0.0694255	0.8994124

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.62049	21	0.0310629
Inverse variance weighted	35.48873	22	0.0344217

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0052574	0.0072445	0.4760281

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010874	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8