Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1023)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0434096	0.0998206	0.6680888
Weighted median	23	-0.0545308	0.0537100	0.3099719
Inverse variance weighted	23	-0.0419117	0.0390156	0.2827201
Simple mode	23	-0.1112723	0.0907437	0.2330772
Weighted mode	23	0.0161330	0.0703269	0.8206770

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	10.41399	21	0.9730202
Inverse variance weighted	11.27632	22	0.9705807

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0052396	0.0056424	0.3636395

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003767	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8