Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1022)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0983439	0.0998204	0.3357377
Weighted median	23	0.0539813	0.0595352	0.3645589
Inverse variance weighted	23	0.0446895	0.0390155	0.2520311
Simple mode	23	0.0857288	0.1061541	0.4279736
Weighted mode	23	0.0653863	0.0816524	0.4318178

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.18297	21	0.6999568
Inverse variance weighted	17.52398	22	0.7338089

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0032949	0.0056424	0.5654664

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005708	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8