Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1021)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0687319	0.0998204	0.4986399
Weighted median	23	-0.0336176	0.0543350	0.5361071
Inverse variance weighted	23	-0.0064388	0.0390157	0.8689198
Simple mode	23	-0.0234848	0.0970189	0.8109729
Weighted mode	23	-0.0402272	0.0624640	0.5262289

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.64581	21	0.6712949
Inverse variance weighted	18.31516	22	0.6871473

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0046162	0.0056423	0.422463

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005558	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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