Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1020)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1645577	0.0998199	0.1141219
Weighted median	23	0.0025864	0.0587880	0.9649086
Inverse variance weighted	23	0.0064619	0.0390154	0.8684516
Simple mode	23	0.0003205	0.1075353	0.9976486
Weighted mode	23	-0.0023274	0.0802617	0.9771276

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.17698	21	0.7003235
Inverse variance weighted	20.64161	22	0.5429717

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0105023	0.0056423	0.0767522

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006263	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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