Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 102)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0439353	0.1242747	0.7272126
Weighted median	23	-0.0485902	0.0611747	0.4270292
Inverse variance weighted	23	-0.0760187	0.0475459	0.1098539
Simple mode	23	-0.0721772	0.1123856	0.5273610
Weighted mode	23	-0.0721772	0.0806740	0.3806434

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.55082	21	0.0514412
Inverse variance weighted	32.67276	22	0.0666277

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019702	0.0070246	0.7818561

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001105	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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