Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1019)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0050649	0.1235760	0.9676943
Weighted median	23	0.0102040	0.0593055	0.8633910
Inverse variance weighted	23	0.0026361	0.0471951	0.9554562
Simple mode	23	-0.0578257	0.0984492	0.5629383
Weighted mode	23	-0.0044560	0.0718212	0.9510887

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.18469	21	0.0560764
Inverse variance weighted	32.19172	22	0.0741857

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004729	0.0069851	0.9466619

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009756	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8