Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1018)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0946702	0.0998212	0.3537144
Weighted median	23	-0.0517733	0.0540153	0.3378139
Inverse variance weighted	23	-0.0032621	0.0390159	0.9333674
Simple mode	23	0.0005460	0.0850118	0.9949336
Weighted mode	23	-0.0526491	0.0624539	0.4082967

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.24345	21	0.7558203
Inverse variance weighted	17.23319	22	0.7503619

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056133	0.0056424	0.3311312

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005224	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8