Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1017)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0276852	0.0998206	0.7842238
Weighted median	23	0.0005860	0.0562984	0.9916949
Inverse variance weighted	23	-0.0608778	0.0390156	0.1186783
Simple mode	23	-0.0031818	0.0998062	0.9748556
Weighted mode	23	-0.0031818	0.0720899	0.9651940

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.20566	21	0.7579868
Inverse variance weighted	16.33617	22	0.7988586

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0020384	0.0056424	0.7215141

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005688	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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