Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1016)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1461759	0.1124604	0.2077573
Weighted median	23	0.0883877	0.0537179	0.0998866
Inverse variance weighted	23	0.0191486	0.0444586	0.6666814
Simple mode	23	0.0431845	0.0925414	0.6453379
Weighted mode	23	0.0806917	0.0581453	0.1791072

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.65530	21	0.1825559
Inverse variance weighted	28.56673	22	0.1576514

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0078007	0.0063568	0.2333472

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008729	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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