Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1015)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0721659	0.0998197	0.4776786
Weighted median	23	0.0960615	0.0573141	0.0937273
Inverse variance weighted	23	0.0263951	0.0390154	0.4987036
Simple mode	23	0.0557212	0.1079094	0.6107472
Weighted mode	23	0.1008046	0.0692013	0.1593283

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.72790	21	0.4756656
Inverse variance weighted	20.97606	22	0.5222179

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0028108	0.0056423	0.6235462

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006495	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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