Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1014)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1354418	0.1297376	0.3083699
Weighted median	23	-0.0246699	0.0587245	0.6744161
Inverse variance weighted	23	-0.0266640	0.0505125	0.5975902
Simple mode	23	0.0614045	0.1039914	0.5608882
Weighted mode	23	-0.0188201	0.0765087	0.8079732

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.47519	21	0.0250236
Inverse variance weighted	36.87688	22	0.0244022

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00668	0.0073334	0.3726824

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011316	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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