Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1013)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0222458	0.0998194	0.8257977
Weighted median	23	0.0470308	0.0586340	0.4224907
Inverse variance weighted	23	0.0701846	0.0390154	0.0720354
Simple mode	23	0.0732378	0.0949221	0.4485859
Weighted mode	23	0.0468285	0.0737531	0.5320189

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.15321	21	0.5115764
Inverse variance weighted	20.42544	22	0.5564461

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029439	0.0056423	0.6072962

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000717	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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