Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1012)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1006762	0.0998209	0.3246622
Weighted median	23	0.0208612	0.0523206	0.6900999
Inverse variance weighted	23	-0.0097305	0.0390158	0.8030525
Simple mode	23	-0.0379790	0.0870791	0.6669825
Weighted mode	23	0.0324772	0.0619151	0.6051457

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.77956	21	0.7819063
Inverse variance weighted	17.22349	22	0.7509079

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.00678	0.0056423	0.2428808

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005238	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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