Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1011)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0417749	0.1368746	0.7632141
Weighted median	23	0.0191047	0.0552471	0.7294900
Inverse variance weighted	23	0.0551271	0.0529995	0.2982728
Simple mode	23	-0.0616383	0.0885331	0.4935829
Weighted mode	23	0.0152202	0.0579958	0.7954272

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.48442	21	0.0085861
Inverse variance weighted	40.59672	22	0.0092002

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0059507	0.0077368	0.4503714

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012906	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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