Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1010)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0481104	0.1089477	0.6632986
Weighted median	23	-0.0003955	0.0555986	0.9943249
Inverse variance weighted	23	0.0234547	0.0421057	0.5774971
Simple mode	23	-0.0074840	0.0919666	0.9358777
Weighted mode	23	0.0039883	0.0620976	0.9493702

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.01622	21	0.2464625
Inverse variance weighted	25.62291	22	0.2682240

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0043948	0.0061582	0.4833027

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007874	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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