Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 101)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0971504	0.0998200	0.3415047
Weighted median	23	-0.0233936	0.0588972	0.6912247
Inverse variance weighted	23	0.0381229	0.0390153	0.3285071
Simple mode	23	-0.0210851	0.1096171	0.8492308
Weighted mode	23	-0.0408849	0.0806757	0.6173507

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.41757	21	0.5583722
Inverse variance weighted	19.83031	22	0.5936535

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036249	0.0056424	0.5275368

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006298	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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