Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1009)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0183438	0.1109829	0.8703004
Weighted median	23	0.0083123	0.0548177	0.8794748
Inverse variance weighted	23	0.0106385	0.0424622	0.8021689
Simple mode	23	-0.0108236	0.0865820	0.9016515
Weighted mode	23	0.0127246	0.0634641	0.8429308

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.9592	21	0.2080090
Inverse variance weighted	26.0587	22	0.2491703

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017798	0.0062733	0.77941

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007919	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8