Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1008)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0260405	0.0998212	0.7967332
Weighted median	23	0.0120975	0.0541040	0.8230700
Inverse variance weighted	23	-0.0195118	0.0390158	0.6170053
Simple mode	23	-0.0030363	0.0829016	0.9711141
Weighted mode	23	0.0049723	0.0600725	0.9347814

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.43232	21	0.8927283
Inverse variance weighted	13.67811	22	0.9125087

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027973	0.0056424	0.6252008

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004221	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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