Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1007)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0497536	0.1184138	0.6786311
Weighted median	23	-0.0876197	0.0607507	0.1492225
Inverse variance weighted	23	-0.0422657	0.0452237	0.3499988
Simple mode	23	-0.0526821	0.1069388	0.6271495
Weighted mode	23	-0.0828016	0.0722521	0.2641045

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.55231	21	0.1013604
Inverse variance weighted	29.55895	22	0.1295841

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004598	0.0066933	0.945878

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009312	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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