Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1006)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0704422	0.1220376	0.5699299
Weighted median	23	0.0317212	0.0588381	0.5897985
Inverse variance weighted	23	0.0694693	0.0466027	0.1360482
Simple mode	23	-0.0176615	0.0983715	0.8591579
Weighted mode	23	0.0131415	0.0750441	0.8625893

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.38891	21	0.0674247
Inverse variance weighted	31.38902	22	0.0884257

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-5.97e-05	0.0068982	0.9931712

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010471	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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